Dualgen 5R is one of the few unique 5% Minoxidil solutions available on the market, which also contains Tretinoin 0.025%.
Topical tretinoin application influences the expression of follicular sulfotransferase. It has been shown in this cohort study. Another study compared Minoxidil 5% vs Minoxidil 5% + 0.01% Tretinoin and also confirmed potential benefits of including tretinoin in the topical Minoxidil formulations.
Among very few available Minoxidil solutions with Tretinoin I can highly recommend you Dualgen – 5R (Minoxidil 5%, Tretinoin 0.025%, Azelaic Acid 5%, Adenosine, Biotin and Caffeine).
Although topical application of Biotin hasn’t shown any significant stimulatory benefits on hair growth, Adenosine and Caffeine have been also shown to positively affect the anagen (growing) phase of the hair follicle.
Below you can see the different mechanisms of actions between Minoxidil and Stemoxydine.
Minoxidil helps the hair follicle to stay in the Anagen (growing) phase while Stemoxydine helps it to return back to the Anagen phase after Telogen phase has been completed.
Telogen phase can never be avoided and belongs to a natural regeneration process of the hair follicle.
Patients with androgenetic alopecia may have suboptimal hair follicle growth cycle.
It means that hair follicles may not always pass to the Anagen phase right after the Telogen phase has been completed.
As a result of that, the hair follicle can get stuck in the Kenogen phase and its return to the Anagen phase may be delayed.
Kenogen phase can be further divided into Exogen, when the hair falls out, and Neogen, when the new hair and follicle are developing.
Minoxidil and Stemoxydine are both topical stimulants for more hair growth.
Their efficacy will depend on the stage and severity of patient´s hair loss.
They should be seen as complements. By using both patients can achieve synergistic effects.
Minoxidil is superior to Stemoxydine in terms of efficacy and scientific evidence.
Stemoxydine and Minoxidil can be purchased as over-the-counter medications and cost about the same.
Minoxidil is FDA approved for treating hair loss while Stemoxydine is not.
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