topical finasteride

Use of Topical Finasteride for Hair Loss - Guide

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Topical Finasteride 0.25%: Effective DHT inhibition without using oral Finasteride?

1st important thing you need to be aware of: Topical Finasteride does go systemic and it alters your DHT levels by as much as 80%(1)

Why is it though to be a more side effect – free version of Fiansteride?

Finasteride was originally developed to become a more side effect free version of oral Finasteride. It hasn´t become it yet and this post will explain you why.

Topical Finasteride has been shown to inhibit 70% of DHT on the scalp.(2)

Topical Finasteride vs Oral Finasteride: Effectiveness

topical finasteride studies
Oral Finasteride – outperforming Topical Finasteride slightly in the long run because of cumulative effects

The terminal hairs in finasteride gel group were always more than the finasteride tablet group, until third month of therapy. However, they were similar in both groups during the fourth month of treatment. At 5th and 6th months, the terminal hair counts were more in the group who were receiving tablets, thus explaining the efficacy of the tablet during therapeutic period.”

Study on 45 male patients taking 1mg Finasteride tablet vs 0.1% Finasteride gel(2)

Topical Finasteride doesn´t have a standardized concentration yet and the efficacious concentration is likely lower than 0.25%

0.1 – 0.2 ml of Topical Finasteride 0.25% = Similar DHT inihibition to oral Finasteride with less plasma exposure to Finasteride!

“A strong and similar inhibition of plasma DHT was found after 1 week of treatment with the topical and tablet finasteride formulations, albeit finasteride plasma exposure was significantly lower with the topical than with the oral product.”

Study on 24 male patients taking 1mg Finasteride tablet vs 0.25% Finasteride gel(1)

The study below has shown that 0.1ml – 0.2ml of Topical Finasteride 0.25% has the best ability to inhibit scalp DHT (37% – 54%) with only 24%-26% serum DHT suppression.

topical finasteride best concentration

Best Topical Finasteride concentration for maximizing scalp DHT suppression and minimizing the Finasteride plasma exposure

Caserini Topical FInasteride dose response study

Source: Effects of finasteride on scalp and serum dihydrotestosterone in androgenetic alopecia

Maurizio Caserini, Milko Radicioni, Chiara Leuratti, Emanuela Terragni,
Matilde Iorizzo, and Renata Palmieri
Topical Finasteride best concentration - Matt Dominance

Here´s how Topical Fiansteride dosing works by 0.25% concentration:

Topical Finasteride 0.25% = 2.5 mg Finasteride per 1 ml

This corresponds to:

0.25 mg Finasteride per 0.1 ml

0.5 mg Finasteride per 0.2 ml

1 mg Finasteride per 0.4 ml

5 mg Finasteride per 2 ml

7.5 mg Finasteride per 3 ml

10 mg Finasteride per 4 ml

Is the 0.025% Topical Finasteride the most ideal concentration for maximizing scalp DHT suppression while minimizing the systemic DHT inhibition?

0.025% Topical Finasteride with Stemoxydine

In this post I explain you how to prepare your own 0.025% topical Finasteride solution by using stemoxydine and topical Finasteride which is available online without prescription. Check it out here!

Future topical Finasteride delivery via NLC (nanostructured lipid carriers)

nanostructured lipid carriers and Finasteride delivery

NLCs could be a novel form for application of topical anti hair loss agents/stimulants. The research on nanostructured lipid carriers is focusing on more effective, steady and consistent transdermal absorption of Finasteride.(5)

The success rate of topical anti-hair loss products relying upon transdermal absorption of the scalp can differ.

Since topical Finasteride hasn´t received approval from the FDA yet, there is neither a standardized concentration nor there is a unified way for its topical delivery.

The success of dermatological products in alopecia therapy depends on the capability of the drug to overcome the outermost layer of the epidermis and to penetrate through skin in sufficient amounts.

In order to achieve this effectively NLCs of different length are yet to be researched to deliver anti-alopecia drugs into the dermis and hair follicles.

The optimal outcome would be to achieve high transdermal penetration together with continuous release of topical Finasteride over 24h period. 

How to get Topical Finasteride with prescription vs for research purposes

Topical Finasteride prescription Free

You can get topical Finateride compounded by a pharmacy (prescription required) or you can order it online.

Price of a pharmacy compunded topical Finasteride can be 2-3 times higher than getting topical Finasteride only (for reasearch purposes).

Topical Finasteride for research purposes

In this short blog post I explain how to only get 1 single 60 ml bottle of topical Finasteride and make it last over 1 year while effectively managing your hair loss every day! 

The issue with topical Finasteride products available online is, that their concentrations are unnecessary high e.g 0.1%, 0.2% or even 0.25%. 

By mixing these topical Finasteride solutions with solvents like stemoxydine from Serioxyl or Cerafill you can simply lower the topical Finasteride concentration, get similar effectiveness and make the product last 3 times longer! 

Read more about it here…

Pharmacy compounded Topical Finasteride with prescription

Topical Finasteride
(with prescription)

My experience with pharmacy compounded topical Finasteride

Topical Finasteride from a pharmacy, which I have been using for 6 months.

I haven´t experienced any sexual side effects whatsoever.

The only side effect I experienced initially were slight headaches.

This solution contained 25mg of Finasteride per 1ml (2.5%).

This compund started to work already within the first month of using it daily.

The cost: 45 Euro per 30ml bottle you see on the photo. Sometimes I had to use more than 1ml to sufficiently cover up all the thinning areas which made it last shorter than 1 month.

Topical Finasteride with prescription available by the following physicians:

Topical Finasteride concentrations may vary among physicians and pharmacies

  • Dr. Alan Bauman (Boca Raton, Florida,USA)
  • Dr. Hasson & Wong (Vancouver, Canada)
  • Dr. Carlos Wesley (NYC,USA)
  • Farmaciaparati (Italy/online)
  • Allerheiligen Apotheke (Austria)
  • Dr. Christian Bisanga (Brussels, Belgium)

Conclusion

  • Topical Finasteride is thought to be as a more side effect-free version of oral Finasteride 1mg, which is only true by applying it in a very small quantities like 0.1ml-0.2ml (by a 0.25% solution)
  • Several studies confirmed similar efficacy of Finasteride 1mg vs Finasteride gel 1% or 2.5%. Topical Finasteride shows diminishing marginal returns.
  • Topical Finasteride is able to inhibit DHT more efficiently on the scalp initially as opposed to oral Finasteride. 
  • Systemic DHT suppression of 18% – 19% with only one topical Fiansteride application has been achieved
  • Topical Finasteride ability to inhibit DHT on the scalp and systemically isn´t better (if applied twice a day).
  • The scientific evidence suggests, that oral Finasteride tends to slightly outperform its topical version in the long-run.
  • Topical Finasteride can be bought online (prescription-free) or from a pharmacy (prescriprion required).
  • The quality of topical finasteride may differ from supplier to supplier. It´s important to get your topical Finasteride from a trusted source.
  • Topical Finasteride is not FDA approved with no standardized dose/concentration. Neither there is a unified way of its topical delivery. 
  • NLCs (nanostructured lipid carriers) can be a novel way of applying topical Finasteride for treating androgenic alopecia more effectively.

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6 thoughts on “Use of Topical Finasteride for Hair Loss – Guide​

  1. Hi Pete. The highest concentration of topical Finasteride I was able to find online for purchase was 0.25

  2. Hello

    I see on the picture the pharmacy made finasteride gel contains 2,5% finasteride, per 1 ml. Is this 2.5 or 25 mg of finasteride ?

    (I read 0.1% in 1 ml equites 1 mg. Later I read 2.5 % in 1 ml equites 2.5 mg. One of these figures seem to be off)

    Regards

    Paul

  3. Hi Matt,

    Interesting post.

    I have a question about dosage.

    In the first part you wrote that 0,1% topical finasteride, per ml, contains 1mg of oral finasteride

    In the last part ‘My experience with pharmacy topical finasteride’ I can see a picture of a pharmacy made bottle of finasteride gel of 2.5 %. In the text next to this picture you say that this 2.5% of topical finasteride equites 2.5mg of finasteride, per ml. That seems to contradict to what you said before.

    If 0.1%, per ml, equites 1mg, then 2.5 %, per ml, equites 25 mg. Correct ?

    Anyway, It seems that topical finasteride of 2.5% contains be a very high dosage of finasteride (25gr). It is the equivalent of 25 pills of oral finasteride, per day. Would you agree to that ?

    Regards,

    Paul

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