Let me explain you, how Finasteride, Dutasteride, Minoxidil, RU 58841, topical Finasteride, topical Dutasteride and Microneedling/derma rolling can help you manage your hair loss effectively in 2020!
DISCLAIMER: This anti-hair loss protocol contains not only FDA but also non FDA approved medication!
www.mattdominance.com doesn´t provide any medical advice and its content serves only for educational and informational purpose.
Have you already tried Minoxidil (Rogaine) or Finasteride (Propecia) ?
Did you get side effects or the medication stopped being effective for you?
Please scroll down to this section – “Alternatives to Minoxidil(Rogaine) and Finasteride (Propecia) for hair loss management”
Non FDA approved medication discussed in this post
Dutasteride 0.5 mg
Topical Finasteride 1% – 2.5%
Read this first, if you are entirely new to hair loss management
2% Minoxidil and 5% Minoxidil are both FDA approved for hair loss – related issues by men and women. FDA approved for treating hair loss in 1998 ( 5% solution) and doesn´t require any prescription from a physician.
Efficacy of Minoxidil(Rogaine)
5% version is almost in all cases superior to the 2% Minoxidil solution.
STUDIES – Minoxidil 2% vs 5% in men and women suffering from hair loss
Results in men – 45% more hair regrowth with 5% Minoxidil solution than with 2% Minoxidil solution at week 48.
Results in women – At week 48, the 5% topical minoxidil group demonstrated statistical superiority over the 2% topical minoxidil group.
Results of a Study on Minoxidil and Derma-rolling – 12-week study showed that derma-roller along with Minoxidil treated group was statistically superior to Minoxidil only.
In the Micro-needling group, 41 (82%) patients versus only 2 (4.5%) patients in the Minoxidil group reported more than 50% improvement.
Drawbacks of Minoxidil
- Rare side effects like sudden heart pumps, dry and itchy scalp, faster aging of the skin and face, collagen loss in the skin and increased shedding during the first 1-3 months – part of Minoxidil treatment!
- Doesn´t block DHT and that´s why it´s not sufficient for treating hair loss long-term in most cases.
Finasteride 1mg oral is the standardized FDA approved dose of Finasteride for treating hair loss. FDA approved for treating hair loss in 1997 and requires a prescription from a physician.
Efficacy of Finasteride(Prorpecia)
0.5 mg, 1 mg and 5mg doses show similar efficacy in terms of inhibiting DHT (systemically up to 70%).
Even as low as 0.2 mg Finasteride daily has been shown efficacious for treating hair loss.
5 year STUDY – Finasteride 1mg ( 1553 men)
Results – Finasteride led to durable improvements in scalp hair growth.
10 year STUDY – Finasteride 1mg (523 men)
Drawbacks of Finasteride
- Sexually – related side effects like decreased sex drive, loss of libido, weaker erections or fat gain can occur by roughly 1%-2% of patients who take Finasteride.
5 Tips on Managing your hair loss Effectively using Minoxidil and Finasteride as a “newbie”
- No matter if you decide to go with Minoxidil (Rogaine), Finasteride or both, make sure you stick to them at last 6-12 months to see any results
- If you´re younger than 20, consider starting with Minoxidil 5% (Rogaine). Although Finasteride has been shown as “well tolerated” long-term by 1000´s of users, there was no study conducted on safety profile of Finasteride by teenage guys
- If your hair loss is too aggressive and Minoxidil doesn´t seem to work for you as expected, consider upgrading onto 0.2 – 0.5 mg of Finasteride daily. This dose has been show efficacious almost the same way as the standardized FDA approved dose of 1 mg Finasteride
- As soon as experience sexually-related side effects from Finasteride, consult your physician, consider lowering the dose as low as 0.2 mg/day
- If you can´t tolerate oral Finasteride entirely, consider upgrading onto topical Finasteride, topical Finasteride with Minoxidil, or RU 58841
Alternatives to Minoxidil(Rogaine) and Finasteride (Propecia) for hair loss management
Topical Finasteride 1% – 2.5%
This it the topical Finasteride I am currently using. It´s compounded by a pharmacy and made specifically for you based on the doctor´s prescription.
This bottle has 2.5mg Finasteride per 1ml in it. 1 ml is the daily dose.
“Preliminary results on the use of topical Finasteride are limited, but safe and promising. Check the review of 7 articles discussing the efficacy of topical Finasteride.
This study shows similar therapeutic response of patients using 1 mg Finasteride tablet vs 1% Finasteride gel.
Research on topical Dutasteride is even more limited than research on topical Finasteride.
In theory we can expect similar or better efficacy in comparison to topical Finasteride.
Dutasteride is able to inhibit not only the type 2 but also type 1 and type 3 5-alpha-reductase enzyme. Terefore, slightly better DHT inhibition can be achieved orally.
Topical Dutasteride inhibits type 1 and type 2 5-alpha-reductase on the scalp as well. Is it good? Well, it has been shown that type 1 5-alpha-reductase isn´t expressed in the hair follicles as much as type 2 5-alpha-reductase.
Dutasteride 0.5 mg
Dutasteride (Avodart) is a more potent version of Finasteride regarding the DHT inhibition, but that doesn´t mean it is more effective for hair loss maintenance than Finasteride is.
Dutasteride is able to inhibit the enzyme type 2 5-alpha-reductase the same way Finasteride is.
Moreover Dutasteride is also able to inhibit type 1 and 3 5-alpha-reductase enzymes which makes it undoubtedly more stronger of a DHT inhibitor overall (up to 90-95%).
Despite of that, it´s not the overall amount of DHT blocked in your whole body which matters for hair loss. It´s the amount of DHT blocked on your scalp.
Topical Finasteride and Minoxidil
Minoxidil solutions fortified with topical Finasteride are more common and accessible online than topical Finasteride or topical Dutasteride only.
The concentration of topical Finasteride in these solutions can range from 0.5mg Finasteride per 1ml to 2.5mg Finasteride per 1ml.
Topical finasteride and minoxidil solutions have been shown more efficacious for treating hair loss than Minoxidil solutions only.
RU 58841 is the last of the 5 options I would try, in case none of the Finasteride or Dutasteride solutions (oral or topical) are working for you.
Unfortunately to this day, there was no clinical research made on RU 58841 which could have established its long-term safety and efficacy unlike by Finasteride oral 1 mg.
This makes this solutions more unexplored and risky to use.
For example this study observing efficacy of RU 58841 on mice from 1997 concluded that RU can have potential benefits on hair regrowth and suggested further clinical trial.
Nevertheless, there was no clinical study on RU 58841 conducted to this day.